My research experience started with searching for the way to improve the health of diabetic individuals. It was primarily focused on the neutralization of oxidative stress. The most important finding was that melatonin seems to be up-and-coming agent. The research was done at the University of Warsaw (Poland) during my B.Sc. and M.Sc. studies.
During my Ph.D. studies at the Nencki Institute of Experimental Biology (Polish Academy of Sciences, Warsaw, Poland), I worked on thymidylate synthase – the enzyme being a molecular target of many chemotherapies. My special attention was put towards posttranslational modifications of this protein. One of the most interesting for me was phosphorylation of histidine residues – underestimated labile modification of proteins, also of human origin.
My recent research at the Institute of Biochemistry and Biophysics (Polish Academy of Sciences, Warsaw, Poland) is connected with the toxicity of metal ions, especially nickel and palladium. This toxicity is an urgent problem as a relatively high proportion of the general population suffers from e.g. nickel allergy. However, the actual molecular mechanism of the harmful activity of nickel ions is not fully elucidated. We found that such a mechanism may be connected with damage of annexin A1, A2, or A8 by nickel ions. Protein alpha-1 antitrypsin is another potential target for nickel ions.
I am also involved in research on Aβ peptide to disclose certain aspects of the mechanism of Alzheimer’s Disease development.